Table of Contents
among people with type 2 diabetes (T2D), high levels of arm and trunk fat are associated with an increased risk of cardiovascular disease (CVD) and mortality, and high levels of leg fat are associated with an increased risk of these diseases. associated with decline.
- Evidence shows that people with T2D have a two- to four-fold increased risk of CVD and mortality. obesity Although management can help delay complications and early death, elevated body mass index (BMI) may not be sufficient to measure obesity.
- In the “obesity paradox,” people with a high BMI may have a lower risk of CVD than people of normal weight.
- Researchers studied 21,472 T2D patients (mean age 58.9 years, 60.7% male, BMI approximately 29-33) from UK Biobank (2006-2010) and found that regional body fat accumulation was associated with CVD risk. We prospectively investigated the relationship (2006-2010) and followed up on the median value. 7.7 years.
- Regional body fat distribution in the arms, trunk, and legs was assessed using bioelectrical impedance analysis.
- The primary outcomes were CVD incidence, all-cause mortality, and CVD mortality.
- Participants in the highest quartile of arm fat percentage (multivariate adjusted hazard ratio) [HR]1.63; 95% CI, 1.29-2.05) and trunk fat percentage (HR, 1.27; 95% CI, 1.06-1.52) had a higher risk of CVD than those in the bottom quartile.
- However, participants in the highest quartile of leg fat percentage had a lower risk of cardiovascular disease than those in the lowest quartile (HR, 0.72; 95% CI, 0.58-0.90).
- Nonlinear relationships were observed between higher leg fat percentage and lower CVD risk, and between higher trunk fat percentage and higher CVD risk, but higher arm fat percentage and higher CVD risk were observed. A linear relationship was observed between them.
- The pattern of association was similar for both all-cause and CVD mortality. The overall pattern was similar for men and women.
“Our findings further our understanding of body fat distribution in T2D patients and highlight the importance of considering both body fat amount and location when assessing CVD and mortality risk in T2D patients. “highlights this,” the authors write.
A study led by Zixin Qiu from the School of Public Health, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China, was published. online in Journal of Clinical Endocrinology and Metabolism.
Because body fat was measured only once at the beginning of the study, it was not possible to assess the association of body fat changing over time. Additionally, the findings are primarily based on predominantly White British adults, which may limit generalizability to other population groups. Additionally, diabetes was diagnosed based on self-reported medical history, medications, and symptoms. A1c This suggests that some cases may have gone undetected at baseline.
This research was funded by grants from the National Natural Science Foundation of China, the Science Fund for Excellent Young Researchers of Hubei Province, and the Fundamental Research Fund for the Central Universities. The authors declared that they had no conflicts of interest.