Collection of raw scRNA-seq data For the human islets datasets, raw scRNA-seq FASTQ files (10X Genomics) were downloaded from the Human Pancreas Analysis Program (HPAP) portal (https://hpap.pmacs.upenn.edu) (Table S1). HPAP-young and…
Researchers from the University of Florida’s Diabetes Institute have found an important clue for why the body’s immune system destroys insulin-producing cells in the pancreas, which leads to Type 1…
Allo-Evasion™ 5.0-engineered iPSC beta islets are designed to overcome immune rejection and provide durable glucose control without chronic immunosuppressionCompelling preclinical data demonstrate rapid reversal of diabetes and sustained normoglycemia, human…
Type 1 diabetes is caused by an insufficient production of the hormone insulin by cells in the pancreas called beta cells and estimated to affect 9.5 million people worldwide. Low…
In the short term, glucose homeostasis increases, but long-term fasting during adolescence can impair beta-cell maturation. study: Chronic intermittent fasting impairs beta cell maturation and function in adolescent mice. Image…
Sana Biotechnology Announces Positive Clinical Results in Type 1 Diabetes Study of Pancreatic Islet Cell Transplantation Without Immunosuppression Released by Sana.com on January 7, 2025. Sana Biotechnology, Inc., a company…
Approximately 8 million people worldwide have type 1 diabetes (T1D). It is a chronic autoimmune disease in which the body attacks and destroys its own insulin-producing beta cells (pronounced “beta”)…
AAV8-mediated Mettl3 overexpression in NOD mouse β cells in vivo delays T1D progression. credit: natural cell biology (2024). DOI: 10.1038/s41556-024-01368-0 Approximately 8 million people worldwide have type 1 diabetes (T1D).…