Type 1

CRISPR-edited cells pump out insulin in a person — and evade immune detection

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Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

By

Elie Dolgin

Elie Dolgin is a science journalist in Somerville, Massachusetts.

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In a medical first, researchers report that they have implanted CRISPR-edited pancreas cells into a person with type 1 diabetes. The cells pumped out sugar-regulating insulin for months — without the need for the recipient to take immune-dampening drugs, thanks to gene edits that allowed the cells, collected from a deceased donor, to evade detection by the recipient’s immune system1.

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doi: https://doi.org/10.1038/d41586-025-02802-5

References

Carlsson, P.-O. et al. N. Engl. J. Med. 393, 887–894 (2025).

Article 
PubMed 

Google Scholar 

Reichman, T. W. et al. N. Engl. J. Med. 393, 858–868 (2025).

Article 
PubMed 

Google Scholar 

Wang, S. et al. Cell 187, 6152–6164 (2024).

Article 
PubMed 

Google Scholar 

Herold, K. C. & Pober, J. S. N. Engl. J. Med. 393, 917–921 (2025).

Article 
PubMed 

Google Scholar 

Pizzato, H. A. et al. Stem Cell Rep. 19, 299–313 (2024).

Article 
PubMed 

Google Scholar 

Frederiksen, H. R. et al. Front. Genome Ed. 6, 1403395 (2024).

Article 
PubMed 

Google Scholar 

Zhang, S.-Q. et al. Blood Adv. 9, 254–264 (2025).

Article 
PubMed 

Google Scholar 

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