Fasting proinsulin, fasting C-peptide, and the corresponding proinsulin to C-peptide ratio (PI:C). A and B, observed PI:C (A) and PI:C predicted by the model (B). Trends were generated from repeated measures generalized linear models of fasting PI:C. C, Overall analysis of trends showed that ergocalciferol significantly delayed the decline in AUC C-peptide percentage from baseline compared to placebo. credit: JAMA network open (2024). DOI: 10.1001/jamanetworkopen.2024.1155
A team of medical researchers and physicians from several universities and two hospitals in the United States reports that administering vitamin D is effective.2 Newly diagnosed type 1 diabetes patients may have an extended so-called honeymoon period.
In their research, published in diary JAMA network openthe group conducted a clinical trial involving the administration of vitamin D2 Supplements for children newly diagnosed with diabetes.
Previous studies have shown that most people with type 1 diabetes have about 30% to 50% remaining pancreatic beta cell function at the time of diagnosis (diabetes is caused by the inability of these cells to (occurs when you stop generating the ). In some cases, beta cells can continue to function for months or even years. This period is known as the honeymoon period, as it gives patients time to adapt to the disease and can delay the onset of harmful symptoms.
Most new research into treating or preventing type 1 diabetes involves efforts to prevent beta cells from ceasing insulin production. In this new effort, the research team found evidence that giving vitamin D to newly diagnosed patients can be beneficial.2 The honeymoon period may be prolonged.
The team’s research involved conducting a randomized clinical trial in 36 young volunteer patients with newly diagnosed type 1 diabetes.Some volunteers were given vitamin D2 Some took the supplement weekly for two months, while others took a placebo for the same period. All volunteers underwent regular blood tests.
When looking at data from clinical trials, the research team found that volunteers were given vitamin D.2 The supplement observed an improvement in the insulin secretory capacity of beta cells and a decrease in the PI:C ratio compared to the placebo. They also found that the decrease in %ΔAUC of C-peptide was slower in patients given vitamin supplements, leading to a longer delay in C-peptide loss.
You can expect the effects of vitamin D.2 Although the timing of the honeymoon period varies from patient to patient, any delay in the onset of symptoms can have lifelong beneficial effects.
For more information:
Benjamin Udoka Nwosu et al, Effects of ergocalciferol on β-cell function in new-onset type 1 diabetes, JAMA network open (2024). DOI: 10.1001/jamanetworkopen.2024.1155
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