National childhood type 1 diabetes screening could prevent thousands of emergency diagnoses, UK study shows

A landmark UK study involving tens of thousands of families has shown that childhood screening for type 1 diabetes is effective, laying the groundwork for a UK-wide childhood screening program.

Results from the first phase of the ELSA (Early Surveillance for Autoimmune diabetes) study have been published in The Lancet Diabetes & Endocrinology.

The findings mark a major step toward a future in which type 1 diabetes can be detected in children before symptoms appear.

Currently, over a quarter of children aren’t diagnosed with type 1 diabetes until they are in diabetic ketoacidosis (DKA), a potentially fatal condition that requires urgent hospital treatment. Early detection can dramatically reduce emergency diagnoses and could give children access to new immunotherapy treatments that can delay the need for insulin for years.

Launched in 2022, ELSA is the first UK study of its kind. Led by researchers at the University of Birmingham, the study tested blood samples for autoantibodies, markers of type 1 diabetes that can appear years before symptoms.

We know that risk rises sharply with the number of autoantibodies. Children without autoantibodies are unlikely to develop type 1 diabetes, while those with one autoantibody have a 15% chance of developing the condition within 10 years.

Having two or more autoantibodies indicates the immune system has already started attacking the insulin-producing cells in the pancreas and it is almost certain these children will eventually need insulin therapy. This is known as early-stage type 1 diabetes.

Among the 17,283 children aged 3–13 years who were screened for type 1 diabetes risk at the time of analysis:

75 had one autoantibody, signaling increased future risk.

160 had two or more autoantibodies but did not yet require insulin therapy, indicating early-stage type 1 diabetes.

seven were found to have undiagnosed type 1 diabetes with all needing to start insulin immediately.

Families of children found to have early-stage type 1 diabetes received tailored education and ongoing support to prepare for the eventual onset of type 1 diabetes symptoms and to ensure insulin therapy can begin promptly when needed, reducing the chances of needing emergency treatment. Those with one autoantibody also received ongoing support and monitoring.

Some families were also offered teplizumab, the first ever immunotherapy for type 1 diabetes, which can delay the need for insulin by around three years in people with early-stage type 1 diabetes. Teplizumab was licensed by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK in August 2025 but is not yet available routinely on the NHS.

As of November 2025, more than 37,000 families have signed up to the ELSA program. Building on this strong foundation, the second phase of the research, ELSA 2 has been launched. ELSA 2 will expand screening to all children in the UK aged 2–17 years, with a focus on younger children (2–3 years) and older teenagers (14–17 years). The research team aims to recruit 30,000 additional children across these new age groups.

ELSA 2 will also establish new NHS Early-Stage Type 1 Diabetes Clinics, providing families taking part in the study with clinical and psychological support and creating a clear pathway from screening to diagnosis, monitoring and treatment.

Lead researcher, Parth Narendran, professor of diabetes medicine at the University of Birmingham, said, “We are extremely grateful to all the families who have participated in the study and generously given their time to help understand how a UK-wide screening program could be developed.

“Together with Diabetes UK, Breakthrough T1D and the National Institute for Health and Care Research, we are working toward a future where type 1 diabetes can be detected in a timely manner, and families appropriately supported and treated with medicines to delay the need for insulin.”

Dr. Elizabeth Robertson, director of research and clinical at Diabetes UK, said, “For too many families, a child’s type 1 diabetes diagnosis still comes as a frightening emergency. But that doesn’t have to be the case. Thanks to scientific breakthroughs, we now have the tools to identify children in the very earliest stages of type 1 diabetes—giving families precious time to prepare, avoid emergency hospital admissions, and access treatments that can delay the need for insulin for years.

“The ELSA study is generating the evidence needed to make type 1 diabetes screening a reality for every family in the UK. We’re incredibly grateful to the 37,000 families who’ve already signed up and urge others to get involved. Together, we can transform type 1 diabetes care for future generations.”

Rachel Connor, director of research partnerships at Breakthrough T1D, said, “This is about rewriting the story of type 1 diabetes for thousands of families. Instead of a devastating emergency, we can offer time, choices, and hope. By finding children in the earliest stages, we’re not just preparing families, we’re opening the door to treatments that can delay the need for insulin by years.

“That extra time means childhoods with fewer injections, fewer hospital visits and more normality. Thanks to research like ELSA, what once struck as an unexpected crisis can become an actively managed health care process, changing the course of T1D for the better.”

The findings from ELSA’s first phase signal a major step toward a future in which type 1 diabetes can be detected early, managed proactively, and potentially delayed through immunotherapy. ELSA demonstrates that childhood screening in the UK is feasible, acceptable to families, and capable of preventing emergency diagnoses. Continued research through ELSA 2 will assess how screening can be scaled across the NHS and evaluate its cost-effectiveness.

Type 1 diabetes is a serious and lifelong autoimmune condition affecting up to 400,000 people in the UK. It is caused by an immune system attack on the insulin-producing cells in the pancreas, meaning they can no longer make enough insulin. Rapid diagnosis of type 1 diabetes is essential to avoid life-threatening complications.