Overview of the deep learning workflow utilizing transfer learning for detecting cardiovascular dysfunction from retinal photography. Abbreviations: CAC = coronary artery calcium score; GLS = global longitudinal strain; MPR = myocardial perfusion reserve; LGE = late gadolinium enhancement; LV M/V = left ventricular mass-to-volume ratio. Credit: Scientific Reports (2025). DOI: 10.1038/s41598-025-13468-4
Recent findings have shown that routine eye screening could also be used for early detection of underlying heart disease in people with type 2 diabetes.
This is the finding of a study carried out by University of Leicester researchers, published recently in Scientific Reports.
NIHR Academic Clinical Lecturer in Cardiology at the University of Leicester, Dr. Gaurav Gulsin, said, “In people with type 2 diabetes, high blood sugar levels damage small and large blood vessels around the body, which results in conditions such as diabetic eye disease. Routine screening using digital photography to look for blood vessel changes in the eyes has been performed for many years in people with type 2 diabetes. These same photographs can help identify people who may also have changes in the heart.
“When we carry out eye screening, we look at the retina, the light-sensitive tissue at the back of the eye. Damage here makes blood vessels swell, leak or close off, preventing the retina from getting enough oxygen, leading to vision problems. We wanted to know if what we can see using digital retinal photography is also signaling underlying structural and functional alterations in the heart, with the aim of catching signs of cardiovascular disease early.”
To do this, 255 patients with type 2 diabetes underwent a number of non-invasive cardiac imaging techniques at Leicester’s Glenfield Hospital to examine the structure and function of their heart. The results were compared to each patient’s digital retinal photograph.
“We found that the presence of diabetic retinopathy was associated with silent cardiovascular disease, including higher burden of coronary artery disease and signs of early heart failure,” stated Dr. Gulsin.
“This association allows us to suggest that results from routine screening for diabetic retinopathy should also be used as an indication of a patient’s heart health—providing an opportunity for early intervention and an effective alternative to current screening tests.”
Publication details
Abbas S. Alatrany et al, The retina as a window into detecting subclinical cardiovascular disease in type 2 diabetes, Scientific Reports (2025). DOI: 10.1038/s41598-025-13468-4
Journal information:
Scientific Reports
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University of Leicester
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Routine eye screening provides a window to heart health in type 2 diabetes (2026, January 20)
retrieved 21 January 2026
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