1. Nanoparticle therapy has potential to reprogram the immune system in type 1 diabetes
COUR Pharmaceuticals is about to begin a phase 1b/2a study to assess a therapy for type 1 diabetes that prevents islet cell destruction and triggers a T cell response.
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2. Cuts to indirect research costs to impact type 1 diabetes
Aaron J. Kowalski, Ph.D., CEO of Breakthrough T1D, spoke with Managed Healthcare Executive about the possible impacts of the NIH’s cuts to indirect research funding.
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3. Diabetes Association updates guidelines for type 1 diabetes
The updated guidelines from the American Diabetes Association emphasize the use of antibody-based screening for type 1 diabetes and recommend that physicians discuss potential use of Tzield, a monoclonal antibody approved to delay the onset of the symptoms of the disease.
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4. New type of stem cell transplant shows promise in type 1 diabetes
Sana Biotechnology’s hypoimmune platform enables it to make a series of genetic modifications to cells, rendering the cells invisible to a patient’s immune system.
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5. Phase 3 trial of Vertex’s islet cell therapy for type 1 diabetes under way
Zimislecel is an allogeneic stem cell-derived islet cell therapy that could eliminate the need for insulin in those who have type 1 diabetes. Regulatory submissions are expected in 2026, and if approved, would be the second cell therapy for type 1 diabetes.
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