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Ultra-low calorie diet improves some diabetes parameters

by Marie Benz MD FAAD
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Ultra-low calorie diet improves some diabetes parameters

Dr. Guofang Chen Endocrinology and Diabetes Center Jiangsu Chinese and Western Medicine Integrated Hospital Nanjing University of Traditional Chinese Medicine

Dr. Chen Guofang

MedicalResearch.com interview:
Chen Guofang, MD
Endocrine and Diabetes Center
Jiangsu Provincial Hospital that integrates Chinese and Western medicine
Nanjing University of Traditional Chinese Medicine

Medical research: What is the background of this study? What are the main findings?
Dr. Chen Guofang: Given the high prevalence of diabetes in China (approximately 11.6% among adults according to 2013 data), there is an urgent need to find ways to improve diabetes remission and reduce the risk of developing diabetes. A very low calorie diet (VLCD) has been reported as a rapid therapeutic tool to improve glycemic control in obese she-type 2 diabetic patients. We investigated the effects of a short-term, very low-calorie diet in both a lean Chinese patient and an overweight/obese patient with type 2 diabetes. In Chinese patients with type 2 diabetes, short-term VLCD was found to improve insulin sensitivity, beta-cell function, glycemic control, and lipid profile more effectively in overweight/obese patients than in lean patients.

Medical research: What should clinicians and patients learn from your report?

Dr. Chen Guofang: We all know that diet and exercise are the cornerstones of blood sugar control in both diabetics and prediabetes. However, maintaining long-term dietary interventions is a daunting task for them. A very low calorie diet gives you the option of continuing with the mandatory diet in the hospital. When patients see significant changes in their body weight and metabolic parameters, they are more motivated to adhere to caloric restriction therapy after discharge.

For patients with new-onset type 2 diabetes or obese prediabetics, a very low-calorie diet may be considered as a first choice, which may prevent them from taking various medications. there is.

Medical Research: What recommendations are made for future research as a result of this study?

Dr. Chen Guofang: So far, the long-term results of very low-calorie diets remain controversial, with weight recovery and maintenance of metabolic improvements still a problem. It is claimed that the weight will be regained as soon as the patient is transferred to a re-feeding diet. Long-term follow-up is then needed to reveal the final effects of VLCD and encourage patients to continue with a healthy diet.


Diabetes Meta Tab. 2015 10 1. pii: S1262-3636(15)00121-4. doi: 10.1016/j.diabet.2015.09.003. [Epub ahead of print]

Effects of a very low calorie diet on insulin sensitivity and insulin secretion in overweight/obese and lean type 2 diabetic patients.

Liu C1, Lee C1, Chen J.2, Liu Yi1, Chen Q2, Shan X2, Chen G3.


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Chen Guofang, MD (2015).Ultra-low calorie diet improves some diabetes parameters

Last updated: October 14, 2015 by Marie Benz MD FAAD


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