Home Type 1CRISPR-edited cells pump out insulin in a person — and evade immune detection

CRISPR-edited cells pump out insulin in a person — and evade immune detection

by furtherReadingSection
0 comments Donate
D41586 025 02802 5 51421798

Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

]]>

Access options

]]>

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

li:not(:first-child)::before {
transform: translateY(-50%);
content: “”;
height: 1rem;
position: absolute;
top: 50%;
left: 0;
border-left: 2px solid #999;
}
.LiveAreaSection .additional-login > li:not(:first-child) {
padding-left: 10px;
}
.LiveAreaSection .additional-login > li {
display: inline-block;
position: relative;
vertical-align: middle;
padding-right: 10px;
}
.BuyBoxSection {
display: flex;
flex-wrap: wrap;
flex: 1;
flex-direction: row-reverse;
margin: -30px -15px 0;
}
.BuyBoxSection .box-inner {
width: 100%;
height: 100%;
padding: 30px 5px;
display: flex;
flex-direction: column;
justify-content: space-between;
}
.BuyBoxSection p {
margin: 0;
}
.BuyBoxSection .readcube-buybox {
background-color: #f3f3f3;
flex-shrink: 1;
flex-grow: 1;
flex-basis: 255px;
background-clip: content-box;
padding: 0 15px;
margin-top: 30px;
}
.BuyBoxSection .subscribe-buybox {
background-color: #f3f3f3;
flex-shrink: 1;
flex-grow: 4;
flex-basis: 300px;
background-clip: content-box;
padding: 0 15px;
margin-top: 30px;
}
.BuyBoxSection .subscribe-buybox-nature-plus {
background-color: #f3f3f3;
flex-shrink: 1;
flex-grow: 4;
flex-basis: 100%;
background-clip: content-box;
padding: 0 15px;
margin-top: 30px;
}
.BuyBoxSection .title-readcube,
.BuyBoxSection .title-buybox {
display: block;
margin: 0;
margin-right: 10%;
margin-left: 10%;
font-size: 24px;
line-height: 32px;
color: #222;
text-align: center;
font-family: Harding, Palatino, serif;
}
.BuyBoxSection .title-asia-buybox {
display: block;
margin: 0;
margin-right: 5%;
margin-left: 5%;
font-size: 24px;
line-height: 32px;
color: #222;
text-align: center;
font-family: Harding, Palatino, serif;
}
.BuyBoxSection .asia-link,
.Link-328123652,
.Link-2926870917,
.Link-2291679238,
.Link-595459207 {
color: #069;
cursor: pointer;
text-decoration: none;
font-size: 1.05em;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 1.05em6;
}
.BuyBoxSection .access-readcube {
display: block;
margin: 0;
margin-right: 10%;
margin-left: 10%;
font-size: 14px;
color: #222;
padding-top: 10px;
text-align: center;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 20px;
}
.BuyBoxSection ul {
margin: 0;
}
.BuyBoxSection .link-usp {
display: list-item;
margin: 0;
margin-left: 20px;
padding-top: 6px;
list-style-position: inside;
}
.BuyBoxSection .link-usp span {
font-size: 14px;
color: #222;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 20px;
}
.BuyBoxSection .access-asia-buybox {
display: block;
margin: 0;
margin-right: 5%;
margin-left: 5%;
font-size: 14px;
color: #222;
padding-top: 10px;
text-align: center;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 20px;
}
.BuyBoxSection .access-buybox {
display: block;
margin: 0;
margin-right: 10%;
margin-left: 10%;
font-size: 14px;
color: #222;
opacity: 0.8px;
padding-top: 10px;
text-align: center;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 20px;
}
.BuyBoxSection .price-buybox {
display: block;
font-size: 30px;
color: #222;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
padding-top: 30px;
text-align: center;
}
.BuyBoxSection .price-buybox-to {
display: block;
font-size: 30px;
color: #222;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
text-align: center;
}
.BuyBoxSection .price-info-text {
font-size: 16px;
padding-right: 10px;
color: #222;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
}
.BuyBoxSection .price-value {
font-size: 30px;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
}
.BuyBoxSection .price-per-period {
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
}
.BuyBoxSection .price-from {
font-size: 14px;
padding-right: 10px;
color: #222;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 20px;
}
.BuyBoxSection .issue-buybox {
display: block;
font-size: 13px;
text-align: center;
color: #222;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 19px;
}
.BuyBoxSection .no-price-buybox {
display: block;
font-size: 13px;
line-height: 18px;
text-align: center;
padding-right: 10%;
padding-left: 10%;
padding-bottom: 20px;
padding-top: 30px;
color: #222;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
}
.BuyBoxSection .vat-buybox {
display: block;
margin-top: 5px;
margin-right: 20%;
margin-left: 20%;
font-size: 11px;
color: #222;
padding-top: 10px;
padding-bottom: 15px;
text-align: center;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: 17px;
}
.BuyBoxSection .tax-buybox {
display: block;
width: 100%;
color: #222;
padding: 20px 16px;
text-align: center;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
line-height: NaNpx;
}
.BuyBoxSection .button-container {
display: flex;
padding-right: 20px;
padding-left: 20px;
justify-content: center;
}
.BuyBoxSection .button-container > * {
flex: 1px;
}
.BuyBoxSection .button-container > a:hover,
.Button-505204839:hover,
.Button-1078489254:hover,
.Button-2737859108:hover {
text-decoration: none;
}
.BuyBoxSection .btn-secondary {
background: #fff;
}
.BuyBoxSection .button-asia {
background: #069;
border: 1px solid #069;
border-radius: 0;
cursor: pointer;
display: block;
padding: 9px;
outline: 0;
text-align: center;
text-decoration: none;
min-width: 80px;
margin-top: 75px;
}
.BuyBoxSection .button-label-asia,
.ButtonLabel-3869432492,
.ButtonLabel-3296148077,
.ButtonLabel-1636778223 {
display: block;
color: #fff;
font-size: 17px;
line-height: 20px;
font-family: -apple-system, BlinkMacSystemFont, “Segoe UI”, Roboto,
Oxygen-Sans, Ubuntu, Cantarell, “Helvetica Neue”, sans-serif;
text-align: center;
text-decoration: none;
cursor: pointer;
}
.Button-505204839,
.Button-1078489254,
.Button-2737859108 {
background: #069;
border: 1px solid #069;
border-radius: 0;
cursor: pointer;
display: block;
padding: 9px;
outline: 0;
text-align: center;
text-decoration: none;
min-width: 80px;
max-width: 320px;
margin-top: 20px;
}
.Button-505204839 .btn-secondary-label,
.Button-1078489254 .btn-secondary-label,
.Button-2737859108 .btn-secondary-label {
color: #069;
}
.uList-2102244549 {
list-style: none;
padding: 0;
margin: 0;
}
/* style specs end */]]]]>]]>

Additional access options:

doi: https://doi.org/10.1038/d41586-025-02802-5

References

Carlsson, P.-O. et al. N. Engl. J. Med. 393, 887–894 (2025).

Article 
PubMed 

Google Scholar 

Reichman, T. W. et al. N. Engl. J. Med. 393, 858–868 (2025).

Article 
PubMed 

Google Scholar 

Wang, S. et al. Cell 187, 6152–6164 (2024).

Article 
PubMed 

Google Scholar 

Herold, K. C. & Pober, J. S. N. Engl. J. Med. 393, 917–921 (2025).

Article 
PubMed 

Google Scholar 

Pizzato, H. A. et al. Stem Cell Rep. 19, 299–313 (2024).

Article 
PubMed 

Google Scholar 

Frederiksen, H. R. et al. Front. Genome Ed. 6, 1403395 (2024).

Article 
PubMed 

Google Scholar 

Zhang, S.-Q. et al. Blood Adv. 9, 254–264 (2025).

Article 
PubMed 

Google Scholar 

Download references

Subjects

Latest on:

You may also like

Today’s Diabetes News, your ultimate destination for up-to-date and insightful information on diabetes, health tips, and living a fulfilling life with diabetes. Our mission is to empower and support individuals with diabetes, their loved ones, and the wider community by providing reliable, relevant, and engaging content that fosters a healthier and happier life.

Most Viewed Articles

Latest Articles

Are you sure want to unlock this post?
Unlock left : 0
Are you sure want to cancel subscription?
Show/Hide Player
-
00:00
00:00
Update Required Flash plugin
-
00:00
00:00