Cells

A graphical representation of pancreatic islet cells attached to strings bobbing up and down like a marionette. Credit: Gloria Fuentes The cells in your pancreas, like people, can only handle …

The cells in your pancreas, like people, can only handle so much stress before they start to break down. Certain stressors, such as inflammation and high blood sugar, contribute to …

TCF1+TOX+ cell populations colocalize to the peri-islet area in human T1D. Credit: Journal of Clinical Investigation (2026). DOI: 10.1172/jci196445 Type 1 diabetes isn’t an overnight attack against the body’s ability …

The mice had to climb a 70-centimeter staircase while carrying a weight attached to their tails to simulate strength training. Credit: Leandro Moura Just seven days of strength training increased …

Their findings pointed to microglia—the brain’s resident immune cells (pictured above)—as a key site of activity. This genetic pattern was consistent across developmental stages, from fetal life to adulthood. “The …

Hospitals can license this animation for patient education and content marketing initiatives. Learn more: …

Key Insights A proof-of-concept trial in a single patient has shown that genetically engineered pancreas cells can survive transplantation without immunosuppression. The results represent a watershed moment for both researchers …

Scientists have long known that people living at high altitudes, where oxygen levels are low, have lower rates of diabetes than people living closer to sea level. But the mechanism …

Collection of raw scRNA-seq data For the human islets datasets, raw scRNA-seq FASTQ files (10X Genomics) were downloaded from the Human Pancreas Analysis Program (HPAP) portal (https://hpap.pmacs.upenn.edu) (Table S1). HPAP-young and …

Grattoni, A. et al. Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead. Nat. Rev. Endocrinol. 21, 14–30 (2025). Article  PubMed  Google Scholar  Bluestone, J. …